NEW YORK, NY / ACCESSWIRE / December 3, 2019 / Kadmon Holdings, Inc. (NYSE:KDMN) today announced that longer-term follow-up results from KD025-208, its ongoing Phase 2 study of KD025 in chronic graft-versus-host disease (cGVHD), will be presented in an oral session at the 61st American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando, FL.
The updated KD025-208 data showed continued improvement, with the Overall Response Rate (ORR) increasing to 65% across the modified intent to treat (mITT) population. KD025 continues to be well tolerated and approximately one-quarter of patients remain on KD025 for longer than a year and a half.
Earlier this month, Kadmon announced that the primary endpoint was met in the planned interim analysis of ROCKstar (KD025-213), the fully enrolled pivotal trial of KD025 in cGVHD patients who had received at least two prior lines of systemic therapy. The study showed clinically and statistically significant ORRs of 64% and 67% across the two dose groups. Additional data from the ROCKstar study are expected in Q1 2020.
In addition, results from an analysis supported by Kadmon that modeled U.S. cGVHD prevalence, prescribing patterns and healthcare costs will be presented in a poster session at ASH.
Details of the presentations are as follows:
KD025-208 Oral Presentation
Title: KD025 for Patients with Chronic Graft-Versus-Host Disease (cGVHD) - Long-Term Follow-up of a Phase 2a Study (KD025-208)
Presenter: Madan Jagasia, MBBS, MS, MMHC, Vanderbilt University Medical Center, Nashville, TN
Session Title: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstruction: Mechanisms of and Therapies for cGVHD
Session Date and Time: Monday, December 9, 2019, 4:30 - 6:30 p.m. ET
Location: Orlando Orange County Convention Center, W230, Level 2
Abstract #: 872
cGVHD Epidemiology Poster
Title: Epidemiology and Real-World Treatment of Chronic Graft-Versus-Host Disease Post Allogeneic Hematopoietic Cell Transplantation: A U.S. Claims Analysis
Presenters: Carlos R. Bachier, MD, Sarah Cannon Center for Blood Cancer, Sarah Cannon Blood Cancer Network, Nashville, TN, and Marcello Rotta, MD, Colorado Blood Cancer Institute, Sarah Cannon Blood Cancer Network, Denver, CO
Session Title: 901. Health Services Research - Non-Malignant Conditions: Poster I
Session Date and Time: Saturday, December 7, 2019, 5:30 - 7:30 p.m. ET
Location: Orlando Orange County Convention Center, Hall B, Level 2
Abstract #: 2109
About Kadmon
Kadmon is a biopharmaceutical company developing innovative products for significant unmet medical needs. Our product pipeline is focused on inflammatory and fibrotic diseases as well as immuno-oncology.
Forward Looking Statements
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CONTACT:
Ellen Cavaleri, Investor Relations
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SOURCE: Kadmon Holdings, Inc.