VANCOUVER, BC / ACCESSWIRE / May 17, 2023 / Gemina Laboratories Ltd. (CSE:GLAB)(FRA:8I7) (the "Company" or "Gemina") is delighted to announce that its patented chemistry for Antibody Immobilization allows for a massive reduction in antibody usage when used in lateral flow assay ("LFA") diagnostic tests.
This represents the confirmation of a major technical milestone on the LFA format for Gemina. The Antibody Immobilization Platform allows for the reduction of test line antibody requirements by 75% vs. standard physisorption, without impacting limit-of-detection.
Gemina's Antibody Immobilization Platform creates a bridge (the "Gemina Bridge") between a sensor surface and the antibodies stuck on that surface for target capture. Use of the Gemina Bridge results in optimized antibody usage and increased target capture activity per unit area of sensor surface. Therefore, use of the Gemina Bridge imparts both significant performance advantages and significant manufacturing advantages with LFA tests.
The industry standard antibody immobilization technique on nitrocellulose used in LFAs - non-specific physisorption, results in only 5-20% of the antibodies deposited on a sensor being "active" or capable of target capture. The Gemina Bridge rescues this lost antibody activity, meaning much less antibody is required to deliver the same test performance. To view a video demonstration, please click here.
Laboratory Study
This massive reduction in antibody requirements was thoroughly demonstrated on the lateral flow assay test line with a COVID-19 rapid antigen test developed by Gemina Labs at the RAPIvD laboratories in Sharnbrook, UK. Instead of striping the antibodies directly onto the nitrocellulose (NC) strip, the Gemina Bridge is first stripped down to form a closely-packed monolayer, onto which the antibodies form a dense secondary layer with four times higher target capture activity than standard antibody-only test lines.
A White Paper highlighting the findings can be accessed here.
Modeling Study
Dr. Robert Davies, an independent surface chemist expert, specializing in lateral flow assay development, was engaged by Gemina Laboratories to model the adsorption of the Gemina Antibody Immobilization Bridge to nitrocellulose, in comparison to optimal close packing of non-specifically adsorbed IgG antibodies. Calculations support the creation of four times more antibody immobilization sites per unit of surface area with the Gemina Bridge, as highlighted in the above-linked white paper.
Summary
In summary, the Gemina Antibody Immobilization Platform acts as a bridge between a sensor surface, in this instance the nitrocellulose test strip in a lateral flow assay, and the antibody used for target capture. Modeling data and internal experimental results indicate that use of the Gemina Bridge increases the density of active antibodies on the test strip by four times versus standard immobilization methods, meaning 75% less antibody is needed with the Gemina Bridge to achieve the same performance as a standard test. This represents a massive savings in antibody consumption during test fabrication.
Robert Greene, Gemina's CTO stated, "In light of the performance we've seen with the Gemina immobilization chemistry, the industry standard for optimal antibody usage on lateral flow assays stands to be significantly revised. We've shown that more can be done with much less, which is a critical step in the creation of affordable, high-quality diagnostics."
"I've been developing lateral flow assays for 35 years, and the Gemina Bridge is the first chemistry that I've worked with that allows for such a marked reduction in antibody requirements while still delivering the quality I demand of the tests we develop at RAPIvD," stated Robert Porter, Gemina's President & CEO of RAPIvD. "This breakthrough is truly a game changer for LFA's and diagnostics."
On Behalf of the Board of Directors
John Davies
Chairman
Gemina Laboratories Ltd.
About Gemina Laboratories Ltd.
Gemina Labs is a biosensor and diagnostic company with a transformative, patented, proprietary chemistry that powers next-generation testing platforms for a wide range of pathogens that affect human health and wellness. Our technology drives testing platforms that are fast, affordable and accurate, and easily self-administered. Our development pipeline includes platforms for the rapid testing of COVID-19, influenza and other viruses. Additional information on the Company can be found at www.geminalabs.com.
Neither the Canadian Securities Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this Release.
Forward Looking Statements
This news release includes forward-looking information and statements, which may include, but are not limited to, information and statements regarding or inferring the future business, operations, financial performance, prospects, and other plans, intentions, expectations, estimates, and beliefs of the Company. Such statements include statements regarding the anticipated terms of any proposed transaction or engagement. Information and statements which are not purely historical fact are forward-looking statements. Forward-looking information and statements involve and are subject to assumptions and known and unknown risks, uncertainties, and other factors which may cause actual events, results, performance, or achievements of the Company to be materially different from future events, results, performance, and achievements expressed or implied by forward-looking information and statements herein. Although the Company believes that any forward-looking information and statements herein are reasonable, in light of the use of assumptions and the significant risks and uncertainties inherent in such information and statements, there can be no assurance that any such forward-looking information and statements will prove to be accurate, and accordingly readers are advised to rely on their own evaluation of such risks and uncertainties and should not place undue reliance upon such forward-looking information and statements. Furthermore, the Company is presently unable to fully quantify the impact that the Covid-19 pandemic will have on its operations and recognizes that certain eventualities may affect planned or assumed performance moving forward. As such, any forward-looking information and statements herein are made as of the date hereof, and except as required by applicable laws, the Company assumes no obligation and disclaims any intention to update or revise any forward-looking information and statements herein or to update the reasons that actual events or results could or do differ from those projected in any forward looking information and statements herein, whether as a result of new information, future events or results, or otherwise, except as required by applicable laws.
For more information regarding the Company, please contact:
Glen Axelrod
Bristol Capital Limited Telephone: 905-326-1888
Email: [email protected]
SOURCE: Gemina Laboratories Ltd.